Fig. 7
From: Effects of amiodarone on short QT syndrome variant 3 in human ventricles: a simulation study
Membrane potential heterogeneity (δV) between single ENDO, MIDDLE and EPI cells and transmural APD90 distribution and its spatial gradient in 1D fiber model for the WT, WT-D172N, D172N and amiodarone-in-action conditions. a, b ENDO, MIDDLE and EPI APs in WT-D172N and WT-D172N + low amiodarone conditions. c, d Corresponding plots of δV against time for the two conditions. Horizontal dashed lines mark peak ENDO-MIDDLE and MIDDLE-EPI δV in WT-D172N condition. e, f Maximal δV observed during repolarization (ENDO-MIDDLE) under WT-D172N and D172N conditions in the presence of amiodarone, respectively. Horizontal dashed lines mark peak ENDO-MIDDLE δV in WT condition. g Spatial distribution of APD90 on 1D fiber model in WT, WT-D172N and amiodarone-in-action conditions. h Spatial gradient of APD90 on 1D fiber model in WT, WT-D172N and amiodarone-in-action conditions. i, j The maximal spatial gradient of APD90 under WT-D172N and D172N conditions in the presence of amiodarone, respectively