Table 1 Values of the model parameters
Parameter | Description | Value | Unit |
|---|---|---|---|
\(q_{a}\) | Gene activation | \(2.78*10^{-4}\) | 1/s |
\(q_{d1}\) | Gene deactivation | \(2.78*10^{-4}\) | 1/s |
\(q_{d2}\) | Spontaneous gene deactivation (negative feedback) | \(2.78*10^{-5}\) | 1/s |
\(q_{d2A}\) | Protein induced gene deactivation (negative feedback) | \(1.565*10^{-9}\) | 1/s |
\(q_{d3}\) | Spontaneous gene deactivation (positive feedback) | \(2.4*10^{-3}\) | 1/s |
\(q_{d3A}\) | Protein induced gene activation (positive feedback) | \(4.8*10^{-5}\) | 1/s |
\(t_1\) | mRNA transcription | 0.05 | Molecules/s |
\(t_2\) | Protein translation | 0.1 | 1/s |
\(d_1\) | mRNA degradation | \(1.5*10^{-4}\) | 1/s |
\(d_2\) | Protein degradation | \(2.0822*10^{-4}\) | 1/s |
\(d_3\) | Protein degradation dependent on drug | \(3*10^{-9}\) | 1/s |
DRUG | Number of drug molecules | \(1.4*10^3\) | Molecules |
\(N_A\) | Number of alleles | 2 | Alleles |