TY - JOUR AU - Marx, V. PY - 2013 DA - 2013// TI - Biology: the big challenges of big data JO - Nature VL - 498 UR - https://doi.org/10.1038/498255a DO - 10.1038/498255a ID - Marx2013 ER - TY - JOUR AU - Howe, D. AU - Costanzo, M. AU - Fey, P. AU - Gojobori, T. AU - Hannick, L. AU - Hide, W. AU - Hill, D. P. AU - Kania, R. AU - Schaeffer, M. AU - St Pierre, S. AU - Twigger, S. PY - 2008 DA - 2008// TI - Big data: the future of biocuration JO - Nature VL - 455 UR - https://doi.org/10.1038/455047a DO - 10.1038/455047a ID - Howe2008 ER - TY - JOUR AU - Kniazeff, J. AU - Prézeau, L. AU - Rondard, P. AU - Pin, J. P. AU - Goudet, C. PY - 2011 DA - 2011// TI - Dimers and beyond: the functional puzzles of class C GPCRs JO - Pharmacol Ther VL - 130 UR - https://doi.org/10.1016/j.pharmthera.2011.01.006 DO - 10.1016/j.pharmthera.2011.01.006 ID - Kniazeff2011 ER - TY - JOUR AU - Katritch, V. AU - Cherezov, V. AU - Stevens, R. C. PY - 2013 DA - 2013// TI - Structure-function of the G protein-coupled receptor superfamily JO - Annu Rev Pharmacol VL - 53 UR - https://doi.org/10.1146/annurev-pharmtox-032112-135923 DO - 10.1146/annurev-pharmtox-032112-135923 ID - Katritch2013 ER - TY - JOUR AU - Wu, H. PY - 2014 DA - 2014// TI - Structure of a class C GPCR metabotropic glutamate receptor 1 bound to an allosteric modulator JO - Science VL - 344 UR - https://doi.org/10.1126/science.1249489 DO - 10.1126/science.1249489 ID - Wu2014 ER - TY - JOUR AU - Doré, A. S. PY - 2014 DA - 2014// TI - Structure of class C GPCR metabotropic glutamate receptor 5 transmembrane domain JO - Nature VL - 551 UR - https://doi.org/10.1038/nature13396 DO - 10.1038/nature13396 ID - Doré2014 ER - TY - JOUR AU - Gao, Q. B. AU - Ye, X. F. AU - He, J. PY - 2013 DA - 2013// TI - Classifying G-protein-coupled receptors to the finest subtype level JO - Biochem Biophy Res Commun VL - 439 UR - https://doi.org/10.1016/j.bbrc.2013.08.023 DO - 10.1016/j.bbrc.2013.08.023 ID - Gao2013 ER - TY - JOUR AU - Larrañaga, P. AU - Calvo, B. AU - Santana, R. AU - Bielza, C. AU - Galdiano, J. AU - Inza, I. AU - Lozano, J. A. AU - Armañanzas, R. AU - Santafé, G. AU - Pérez, A. AU - Robles, V. PY - 2006 DA - 2006// TI - Machine learning in bioinformatics JO - Brief Bioinform VL - 7 UR - https://doi.org/10.1093/bib/bbk007 DO - 10.1093/bib/bbk007 ID - Larrañaga2006 ER - TY - JOUR AU - König, K. AU - Cárdenas, M. AU - Giraldo, J. AU - Alquézar, R. AU - Vellido, A. PY - 2015 DA - 2015// TI - Label noise in subtype discrimination of class C G-protein coupled receptors: a systematic approach to the analysis of classification errors JO - BMC Bioinform VL - 16 UR - https://doi.org/10.1186/s12859-015-0731-9 DO - 10.1186/s12859-015-0731-9 ID - König2015 ER - TY - JOUR AU - Cruz-Barbosa, R. AU - Vellido, A. AU - Giraldo, J. PY - 2015 DA - 2015// TI - The influence of alignment-free sequence representations on the semi-supervised classification of Class C G protein-coupled receptors JO - Med Biol Eng Comput VL - 53 UR - https://doi.org/10.1007/s11517-014-1218-y DO - 10.1007/s11517-014-1218-y ID - Cruz-Barbosa2015 ER - TY - STD TI - Shkurin, A, Vellido A. Random forests for quality control in G-protein coupled receptor databases. In: Ortuño F, Rojas I, eds. Bioinformatics and biomedical engineering. Proceedings. of the 4th international conference (IWBBIO 2016); 2016, LNCS/LNBI 9656, p. 707-18. ID - ref11 ER - TY - STD TI - Lord P, Macdonald A, Lyon L, Giaretta D. From data deluge to data curation. In: Proceedings of the UK e-science All Hands meeting; 2004. p. 371–5 ID - ref12 ER - TY - JOUR AU - Isberg, V. AU - Mordalski, S. AU - Munk, C. AU - Rataj, K. AU - Harpsøe, K. AU - Hauser, A. S. AU - Vroling, B. AU - Bojarski, A. J. AU - Vriend, G. AU - Gloriam, D. E. PY - 2016 DA - 2016// TI - GPCRdb: an information system for G protein-coupled receptors JO - Nucleic Acids Res VL - 44 UR - https://doi.org/10.1093/nar/gkv1178 DO - 10.1093/nar/gkv1178 ID - Isberg2016 ER - TY - STD TI - GLISTEN COST Action CM1207. http://www.glisten-gpcr.eu. Accessed 8 Mar 2017. UR - http://www.glisten-gpcr.eu ID - ref14 ER - TY - STD TI - IUPHAR: International Union of Basic and Clinical Pharmacology. http://www.iuphar.org. Accessed 8 Mar 2017. UR - http://www.iuphar.org ID - ref15 ER - TY - JOUR AU - Cooke, R. M. AU - Brown, A. J. AU - Marshall, F. H. AU - Mason, J. S. PY - 2015 DA - 2015// TI - Structures of G protein-coupled receptors reveal new opportunities for drug discovery JO - Drug Discov Today VL - 20 UR - https://doi.org/10.1016/j.drudis.2015.08.003 DO - 10.1016/j.drudis.2015.08.003 ID - Cooke2015 ER - TY - JOUR AU - Sandberg, M. AU - Eriksson, L. AU - Jonsson, J. AU - Sjöström, M. AU - Wold, S. PY - 1998 DA - 1998// TI - New chemical descriptors relevant for the design of biologically active peptides. A multivariate characterization of 87 amino acids JO - J Med Chem VL - 41 UR - https://doi.org/10.1021/jm9700575 DO - 10.1021/jm9700575 ID - Sandberg1998 ER - TY - STD TI - Cárdenas MI, Vellido A, Giraldo J. Visual interpretation of class C GPCR subtype overlapping from the nonlinear mapping of transformed primary sequences. In: Proceedings of the international conference on biomedical and health informatics (IEEE BHI 2014); 2014. p. 764–7 ID - ref18 ER - TY - JOUR AU - Davies, M. N. AU - Secker, A. AU - Freitas, A. AU - Clark, E. AU - Timmis, J. AU - Flower, D. R. PY - 2008 DA - 2008// TI - Optimizing amino acid groupings for GPCR classification JO - Bioinformatics VL - 24 UR - https://doi.org/10.1093/bioinformatics/btn382 DO - 10.1093/bioinformatics/btn382 ID - Davies2008 ER - TY - JOUR AU - Can Cobanoglu, M. AU - Saygin, Y. AU - Sezerman, U. O. PY - 2011 DA - 2011// TI - Classification of GPCRs using family specific motifs JO - IEEE ACM Trans Comput Biol VL - 8 UR - https://doi.org/10.1109/TCBB.2010.101 DO - 10.1109/TCBB.2010.101 ID - Can Cobanoglu2011 ER - TY - STD TI - Caragea C, Silvescu A, Mitra P. Protein sequence classification using feature hashing. In: Proceedings. of the IEEE international conference on bioinformatics and biomedicine (BIBM 2011); 2011. p. 538–43 ID - ref21 ER - TY - STD TI - Mhamdi F, Elloumi M, Rakotomalala R. Textmining, features selection and datamining for proteins classification. In: Proceedings. of the IEEE international conference on information and communication technologies: from theory to applications, IEEE/ICTTA; 2004. p. 457–8 ID - ref22 ER - TY - JOUR AU - Breiman, L. PY - 2001 DA - 2001// TI - Random forests JO - Mach Learn VL - 45 UR - https://doi.org/10.1023/A:1010933404324 DO - 10.1023/A:1010933404324 ID - Breiman2001 ER - TY - JOUR AU - Boulesteix, A. -. L. AU - Kruppa, J. AU - Konig, I. PY - 2012 DA - 2012// TI - Overview of random forest methodology and practical guidance with emphasis on computational biology and bioinformatics JO - Wiley Interdis Rev Data Mining Knowl Dis VL - 2 UR - https://doi.org/10.1002/widm.1072 DO - 10.1002/widm.1072 ID - Boulesteix2012 ER - TY - JOUR AU - Strobl, C. AU - Boulesteix, A. -. L. AU - Kneib, T. AU - Augustin, T. AU - Zeileis, A. PY - 2008 DA - 2008// TI - Conditional variable importance for random forests JO - BMC Bioinform VL - 9 UR - https://doi.org/10.1186/1471-2105-9-307 DO - 10.1186/1471-2105-9-307 ID - Strobl2008 ER - TY - STD TI - König K, Alquézar R, Vellido A, Giraldo J. Finding class C GPCR subtype-discriminating n-grams through feature selection. In: Proceedings of the 8th international conference on practical applications of computational biology and bioinformatics (PACBB 2014); 2014. p. 89–96 ID - ref26 ER - TY - STD TI - UniProt Database, GPCR Q5I5C3. http://www.uniprot.org/uniprot/Q5I5C3. Accessed 8 Mar 2017. UR - http://www.uniprot.org/uniprot/Q5I5C3 ID - ref27 ER - TY - STD TI - UniProt Database, GPCR B0UYJ3. http://www.uniprot.org/uniprot/B0UYJ3. Accessed 8 Mar 2017. UR - http://www.uniprot.org/uniprot/B0UYJ3 ID - ref28 ER - TY - STD TI - RefSeq: NCBI Reference Sequence Database. http://www.ncbi.nlm.nih.gov/refseq. Accessed 8 Mar 2017. UR - http://www.ncbi.nlm.nih.gov/refseq ID - ref29 ER -