Table 2 Key simulation parameters used in MVIF model

1

Maximum oxygen consumption rate, M ₀

0.0004 cm³/cm³/sec

0.0025 cm³/cm³/sec

2

Saturated hemoglobin concentration \(C'\)

8800 μM

8800 μM [50]

3

\(P_{50}\)

26 mmHg

26 mmHg [50]

4

n in Hill equation

3.0

3.0 [34]

5

Henry’s constant, H

0.74 mmHg/μM

0.74 mmHg/μM [65]

6

Oxygen diffusion constant D

2000 μm²/s

2000 μm²/s [63]

7

Initial pO₂ determination (see “Method” section)

Convert voxel SaO2 using Hill’s equation [64]

8

Effective vessel diameter (see “Method” section)

By all vessel segments within the voxel

9

Effective voxel blood flow (see “Method” section)

By all vessel segments within the voxel

10

Effective SaO₂ (see “Method” section)

Convert intravessel pO₂ to SaO₂ using Hill’s equation