Simulation of developing human neuronal cell networks

Table 3 Lower quartile (Q1), median (M) and upper quartile (Q3) of the calculated features for simulated (INEX) and experimental (MEA) data on measurement time point (MTP) 1–6

Data	Feature	MTP 1			MTP 2			MTP 3
Data	Feature	Q1	M	Q3	Q1	M	Q3	Q1	M	Q3
MEA	SR	2.71	9.53	36.26	8.11	16.99	49.30	14.92	39.45	144.64
	BR	0.07	0.26	1.08	0.09	0.39	0.99	0.88	1.42	5.22
	BD	0.87	5.25	12.65	1.50	2.50	9.65	2.05	6.98	7.55
	SB	1.57	3.16	4.96	2.00	5.00	11.40	3.08	6.33	7.62
INEX	SR	10.98	11.39	11.98	14.19	15.67	17.74	23.04	24.17	26.15
	BR	0.28	0.40	0.57	0.40	0.47	0.62	0.42	0.60	0.84
	BD	13.99	18.09	21.43	6.85	10.17	27.46	11.87	16.56	18.36
	SB	4.15	5.61	6.38	4.02	4.56	10.95	7.00	9.01	10.47
Parameter		\({c}\)	\({y_{ji}^+}\)	\({y_{ji}^-}\)	\({ c}\)	\({y_{ji}^+}\)	\({y_{ji}^-}\)	\({ c}\)	\({y_{ji}^+}\)	\({y_{ji}^-}\)
Parameter		0.07	0.1	−0.1	0.08	0.1	−0.1	0.08	0.3	−0.1

Data	Feature	MTP 4			MTP 5			MTP 6
Data	Feature	Q1	M	Q3	Q1	M	Q3	Q1	M	Q3
MEA	SR	57.10	91.21	163.21	109.76	148.48	224.46	53.68	106.90	113.65
	BR	0.89	4.19	7.19	4.29	5.66	10.69	2.24	2.59	4.79
	BD	0.97	2.79	4.45	2.35	3.71	16.23	1.44	12.68	17.97
	SB	4.16	7.00	19.31	12.18	18.67	45.68	7.19	20.00	24.68
INEX	SR	56.02	57.16	60.39	95.83	100.71	104.10	49.64	54.16	56.28
	BR	2.28	2.67	3.15	4.60	5.34	6.26	1.63	2.06	2.46
	BD	10.05	11.14	12.65	4.18	5.13	5.93	9.67	12.96	15.75
	SB	13.07	14.94	16.46	11.43	13.37	14.15	12.57	15.14	17.97
Parameter		\({ c}\)	\({y_{ji}^+}\)	\({y_{ji}^-}\)	\({ c}\)	\({y_{ji}^+}\)	\({y_{ji}^-}\)	\({ c}\)	\({y_{ji}^+}\)	\({y_{ji}^-}\)
Parameter		0.09	0.5	−0.1	0.09	0.5	−0.1	0.09	0.3	−0.1

The table shows as well the selected upper boundary as result of the parameter space search which resembled best the spike and burst rate of the experimental data (see "Methods" section/ INEX model). The table is visualized in Fig. 3
The spike rate SR is given in spikes per minute, the burst rate BR in bursts per minute, the burst duration BD in seconds and the average number of spikes per burst SB as count.

ISSN: 1475-925X