From: Mechanoresponsive musculoskeletal tissue differentiation of adipose-derived stem cells
Tissue type | In vivo mechanical loading | In vivo strain or stress magnitudes | Ref |
---|---|---|---|
Bone | Fluid shear stress | 0.8–3.0 N/m2 | |
Tensile strain | 0.03–0.1 % (though close to10 % is widely accepted to account for in vivo amplification) | [165] | |
Tendon | Tensile strain | 2–4 % (physiological range) | [57] |
Tensile strain | 5–16 % (complete rupture for mid-tendon) | [66] | |
Skeletal muscle | Tensile stress | 9Â kN (vigorous exercise) | [75] |
Tensile strain | 5-12Â % (moderate activity) | Â | |
Cartilage | Compressive stress | 1–6 MPa (vigorous activity) | [81] |
Compressive strain | 50Â % (at superficial zone) | [62] | |
Compressive Strain | 0–5 % (at deep and middle zone) | [63] |