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Table 1 Evaluation of each of 20 AD subjects

From: Construction and comparative evaluation of different activity detection methods in brain FDG-PET

MNI

CAD4D

SPM

SPM calc

#AD

Max z-score

Cluster size (voxels)

Max t-score (z-score)

Cluster size (voxels)

Max z-score

Cluster size (voxels)

1

7.23

4360

6.25 (5.11)

3198

6.36

4682

2

7.90

20,991

8.92 (6.44)

20,839

9.04

24,226

3

5.57

2495

6.74 (5.39)

2485

6.86

3340

4

5.80

6675

6.60 (5.31)

4556

6.71

6203

5

7.48

6251

6.76 (5.39)

4796

6.87

6628

6

7.53

17,525

7.55 (5.81)

15,977

7.60

19,848

7

6.03

3038

5.94 (4.93)

2257

6.04

3103

8

7.90

25,495

11.30 (7.30)

26,715

11.33

30,529

9

6.62

5260

7.16 (5.61)

5984

7.29

7493

10

7.90

17,031

9.89 (6.83)

15,673

10.27

18,474

11

7.90

20,014

10.59 (7.09)

22,193

10.70

25,979

12

7.90

16,370

9.82 (6.81)

20,141

9.89

23,710

13

7.90

8739

6.60 (5.31)

5990

6.66

8233

14

6.21

2131

6.02 (4.97)

1770

6.10

2895

15

7.63

12,155

7.82 (5.94)

9359

7.91

12,643

16

7.90

15,197

9.46 (6.66)

12,125

9.56

14,529

17

7.90

14,100

8.90 (6.40)

13,161

9.03

15,670

18

7.90

9441

9.16 (6.54)

9707

9.26

9929

19

7.90

2442

8.79 (6.38)

1334

8.86

1764

20

6.68

4117

7.22 (5.64)

2340

7.34

3592

Min

 

2131

 

1334

 

1764

Max

 

25,495

 

26,715

 

30,529

Median

 

9090

 

7654

 

9081

Wilcox

  

CAD4D/SPM

0.057

CAD4D/SPMc

0.012*

     

SPM/SPMc

<0.001*

TAL

CAD4D

SPM

SPM calc

NEUROSTAT

#AD

Max z-score

Cluster size (voxels)

Max t-score (z-score)

Cluster size (voxels)

Max z-score

Cluster size (voxels)

Max z-score

1

6.88

1861

5.56 (4.69)

1179

6.23

2989

5.07

2

7.90

10,106

8.36 (6.19)

11,097

8.96

14,565

8.15

3

6.36

1746

4.92 (4.27)

681

6.58

1805

5.69

4

6.09

1933

5.14 (4.42)

1280

7.20

3441

5.63

5

6.71

3078

6.95 (5.50)

1896

6.94

3954

7.85

6

7.67

7757

6.94 (5.50)

6299

7.79

12,119

7.48

7

6.38

1033

5.19 (4.46)

699

6.15

1751

5.64

8

7.90

13,275

10.41 (7.03)

15,746

10.85

19,129

7.17

9

6.25

2507

7.02 (5.54)

2279

7.30

4304

5.31

10

7.90

7687

9.00 (6.47)

7662

9.91

11,112

6.66

11

7.90

10,550

7.36 (5.71)

5433

10.63

14,914

8.75

12

7.90

8775

8.64 (6.32)

8190

9.83

13,702

7.71

13

6.89

2996

6.30 (5.14)

2691

6.97

4766

6.26

14

6.58

1863

5.46 (4.63)

625

5.98

1647

5.66

15

7.42

5084

6.61 (5.32)

3808

7.88

8205

8.16

16

7.86

6135

8.03 (6.04)

5074

9.57

8538

7.47

17

7.90

7635

8.98 (6.46)

6774

9.01

9136

10.88

18

7.52

5096

8.35 (6.19)

4816

8.74

6709

8.31

19

6.37

914

8.06 (6.06)

774

7.93

1000

7.03

20

7.00

1027

4.83 (4.21)

745

5.83

1872

4.81

Min

 

914

 

625

 

1000

 

Max

 

13,275

 

15,746

 

19,129

 

Median

 

4081

 

3250

 

5738

 

Wilcox

  

CAD4D/SPM

0.006*

CAD4D/SPMc

<0.001*

 
     

SPM/SPMc

<0.001*

 
  1. Extracted maximum z-score/t-score and total hypometabolic cluster size at z > 3 using CAD4D and SPM in MNI space (upper table) and in Talairach space (lower table) compared to the maximum z-score in NEUROSTAT’s 3DSSP; max. z-score and cluster sizes from direct z-score calculation of SPM-normalized images (referred to SPM calc) in MNI and Talairach space. Wilcoxson test statistics (Wilcox) was calculated between the cluster sizes of hypometabolism at z > 3, the asterisk indicates a significance of p < 0.05