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Table 1 Evaluation of each of 20 AD subjects

From: Construction and comparative evaluation of different activity detection methods in brain FDG-PET

MNI CAD4D SPM SPM calc
#AD Max z-score Cluster size (voxels) Max t-score (z-score) Cluster size (voxels) Max z-score Cluster size (voxels)
1 7.23 4360 6.25 (5.11) 3198 6.36 4682
2 7.90 20,991 8.92 (6.44) 20,839 9.04 24,226
3 5.57 2495 6.74 (5.39) 2485 6.86 3340
4 5.80 6675 6.60 (5.31) 4556 6.71 6203
5 7.48 6251 6.76 (5.39) 4796 6.87 6628
6 7.53 17,525 7.55 (5.81) 15,977 7.60 19,848
7 6.03 3038 5.94 (4.93) 2257 6.04 3103
8 7.90 25,495 11.30 (7.30) 26,715 11.33 30,529
9 6.62 5260 7.16 (5.61) 5984 7.29 7493
10 7.90 17,031 9.89 (6.83) 15,673 10.27 18,474
11 7.90 20,014 10.59 (7.09) 22,193 10.70 25,979
12 7.90 16,370 9.82 (6.81) 20,141 9.89 23,710
13 7.90 8739 6.60 (5.31) 5990 6.66 8233
14 6.21 2131 6.02 (4.97) 1770 6.10 2895
15 7.63 12,155 7.82 (5.94) 9359 7.91 12,643
16 7.90 15,197 9.46 (6.66) 12,125 9.56 14,529
17 7.90 14,100 8.90 (6.40) 13,161 9.03 15,670
18 7.90 9441 9.16 (6.54) 9707 9.26 9929
19 7.90 2442 8.79 (6.38) 1334 8.86 1764
20 6.68 4117 7.22 (5.64) 2340 7.34 3592
Min   2131   1334   1764
Max   25,495   26,715   30,529
Median   9090   7654   9081
Wilcox    CAD4D/SPM 0.057 CAD4D/SPMc 0.012*
      SPM/SPMc <0.001*
TAL CAD4D SPM SPM calc NEUROSTAT
#AD Max z-score Cluster size (voxels) Max t-score (z-score) Cluster size (voxels) Max z-score Cluster size (voxels) Max z-score
1 6.88 1861 5.56 (4.69) 1179 6.23 2989 5.07
2 7.90 10,106 8.36 (6.19) 11,097 8.96 14,565 8.15
3 6.36 1746 4.92 (4.27) 681 6.58 1805 5.69
4 6.09 1933 5.14 (4.42) 1280 7.20 3441 5.63
5 6.71 3078 6.95 (5.50) 1896 6.94 3954 7.85
6 7.67 7757 6.94 (5.50) 6299 7.79 12,119 7.48
7 6.38 1033 5.19 (4.46) 699 6.15 1751 5.64
8 7.90 13,275 10.41 (7.03) 15,746 10.85 19,129 7.17
9 6.25 2507 7.02 (5.54) 2279 7.30 4304 5.31
10 7.90 7687 9.00 (6.47) 7662 9.91 11,112 6.66
11 7.90 10,550 7.36 (5.71) 5433 10.63 14,914 8.75
12 7.90 8775 8.64 (6.32) 8190 9.83 13,702 7.71
13 6.89 2996 6.30 (5.14) 2691 6.97 4766 6.26
14 6.58 1863 5.46 (4.63) 625 5.98 1647 5.66
15 7.42 5084 6.61 (5.32) 3808 7.88 8205 8.16
16 7.86 6135 8.03 (6.04) 5074 9.57 8538 7.47
17 7.90 7635 8.98 (6.46) 6774 9.01 9136 10.88
18 7.52 5096 8.35 (6.19) 4816 8.74 6709 8.31
19 6.37 914 8.06 (6.06) 774 7.93 1000 7.03
20 7.00 1027 4.83 (4.21) 745 5.83 1872 4.81
Min   914   625   1000  
Max   13,275   15,746   19,129  
Median   4081   3250   5738  
Wilcox    CAD4D/SPM 0.006* CAD4D/SPMc <0.001*  
      SPM/SPMc <0.001*  
  1. Extracted maximum z-score/t-score and total hypometabolic cluster size at z > 3 using CAD4D and SPM in MNI space (upper table) and in Talairach space (lower table) compared to the maximum z-score in NEUROSTAT’s 3DSSP; max. z-score and cluster sizes from direct z-score calculation of SPM-normalized images (referred to SPM calc) in MNI and Talairach space. Wilcoxson test statistics (Wilcox) was calculated between the cluster sizes of hypometabolism at z > 3, the asterisk indicates a significance of p < 0.05