|
MNI
|
CAD4D
|
SPM
|
SPM calc
|
|---|
|
#AD
|
Max z-score
|
Cluster size (voxels)
|
Max t-score (z-score)
|
Cluster size (voxels)
|
Max z-score
|
Cluster size (voxels)
|
|---|
|
1
|
7.23
|
4360
|
6.25 (5.11)
|
3198
|
6.36
|
4682
|
|
2
|
7.90
|
20,991
|
8.92 (6.44)
|
20,839
|
9.04
|
24,226
|
|
3
|
5.57
|
2495
|
6.74 (5.39)
|
2485
|
6.86
|
3340
|
|
4
|
5.80
|
6675
|
6.60 (5.31)
|
4556
|
6.71
|
6203
|
|
5
|
7.48
|
6251
|
6.76 (5.39)
|
4796
|
6.87
|
6628
|
|
6
|
7.53
|
17,525
|
7.55 (5.81)
|
15,977
|
7.60
|
19,848
|
|
7
|
6.03
|
3038
|
5.94 (4.93)
|
2257
|
6.04
|
3103
|
|
8
|
7.90
|
25,495
|
11.30 (7.30)
|
26,715
|
11.33
|
30,529
|
|
9
|
6.62
|
5260
|
7.16 (5.61)
|
5984
|
7.29
|
7493
|
|
10
|
7.90
|
17,031
|
9.89 (6.83)
|
15,673
|
10.27
|
18,474
|
|
11
|
7.90
|
20,014
|
10.59 (7.09)
|
22,193
|
10.70
|
25,979
|
|
12
|
7.90
|
16,370
|
9.82 (6.81)
|
20,141
|
9.89
|
23,710
|
|
13
|
7.90
|
8739
|
6.60 (5.31)
|
5990
|
6.66
|
8233
|
|
14
|
6.21
|
2131
|
6.02 (4.97)
|
1770
|
6.10
|
2895
|
|
15
|
7.63
|
12,155
|
7.82 (5.94)
|
9359
|
7.91
|
12,643
|
|
16
|
7.90
|
15,197
|
9.46 (6.66)
|
12,125
|
9.56
|
14,529
|
|
17
|
7.90
|
14,100
|
8.90 (6.40)
|
13,161
|
9.03
|
15,670
|
|
18
|
7.90
|
9441
|
9.16 (6.54)
|
9707
|
9.26
|
9929
|
|
19
|
7.90
|
2442
|
8.79 (6.38)
|
1334
|
8.86
|
1764
|
|
20
|
6.68
|
4117
|
7.22 (5.64)
|
2340
|
7.34
|
3592
|
|
Min
| |
2131
| |
1334
| |
1764
|
|
Max
| |
25,495
| |
26,715
| |
30,529
|
|
Median
| |
9090
| |
7654
| |
9081
|
|
Wilcox
| | |
CAD4D/SPM
|
0.057
|
CAD4D/SPMc
|
0.012*
|
| | | | | |
SPM/SPMc
|
<0.001*
|
|
TAL
|
CAD4D
|
SPM
|
SPM calc
|
NEUROSTAT
|
|---|
|
#AD
|
Max z-score
|
Cluster size (voxels)
|
Max t-score (z-score)
|
Cluster size (voxels)
|
Max z-score
|
Cluster size (voxels)
|
Max z-score
|
|---|
|
1
|
6.88
|
1861
|
5.56 (4.69)
|
1179
|
6.23
|
2989
|
5.07
|
|
2
|
7.90
|
10,106
|
8.36 (6.19)
|
11,097
|
8.96
|
14,565
|
8.15
|
|
3
|
6.36
|
1746
|
4.92 (4.27)
|
681
|
6.58
|
1805
|
5.69
|
|
4
|
6.09
|
1933
|
5.14 (4.42)
|
1280
|
7.20
|
3441
|
5.63
|
|
5
|
6.71
|
3078
|
6.95 (5.50)
|
1896
|
6.94
|
3954
|
7.85
|
|
6
|
7.67
|
7757
|
6.94 (5.50)
|
6299
|
7.79
|
12,119
|
7.48
|
|
7
|
6.38
|
1033
|
5.19 (4.46)
|
699
|
6.15
|
1751
|
5.64
|
|
8
|
7.90
|
13,275
|
10.41 (7.03)
|
15,746
|
10.85
|
19,129
|
7.17
|
|
9
|
6.25
|
2507
|
7.02 (5.54)
|
2279
|
7.30
|
4304
|
5.31
|
|
10
|
7.90
|
7687
|
9.00 (6.47)
|
7662
|
9.91
|
11,112
|
6.66
|
|
11
|
7.90
|
10,550
|
7.36 (5.71)
|
5433
|
10.63
|
14,914
|
8.75
|
|
12
|
7.90
|
8775
|
8.64 (6.32)
|
8190
|
9.83
|
13,702
|
7.71
|
|
13
|
6.89
|
2996
|
6.30 (5.14)
|
2691
|
6.97
|
4766
|
6.26
|
|
14
|
6.58
|
1863
|
5.46 (4.63)
|
625
|
5.98
|
1647
|
5.66
|
|
15
|
7.42
|
5084
|
6.61 (5.32)
|
3808
|
7.88
|
8205
|
8.16
|
|
16
|
7.86
|
6135
|
8.03 (6.04)
|
5074
|
9.57
|
8538
|
7.47
|
|
17
|
7.90
|
7635
|
8.98 (6.46)
|
6774
|
9.01
|
9136
|
10.88
|
|
18
|
7.52
|
5096
|
8.35 (6.19)
|
4816
|
8.74
|
6709
|
8.31
|
|
19
|
6.37
|
914
|
8.06 (6.06)
|
774
|
7.93
|
1000
|
7.03
|
|
20
|
7.00
|
1027
|
4.83 (4.21)
|
745
|
5.83
|
1872
|
4.81
|
|
Min
| |
914
| |
625
| |
1000
| |
|
Max
| |
13,275
| |
15,746
| |
19,129
| |
|
Median
| |
4081
| |
3250
| |
5738
| |
|
Wilcox
| | |
CAD4D/SPM
|
0.006*
|
CAD4D/SPMc
|
<0.001*
| |
| | | | | |
SPM/SPMc
|
<0.001*
| |
- Extracted maximum z-score/t-score and total hypometabolic cluster size at z > 3 using CAD4D and SPM in MNI space (upper table) and in Talairach space (lower table) compared to the maximum z-score in NEUROSTAT’s 3DSSP; max. z-score and cluster sizes from direct z-score calculation of SPM-normalized images (referred to SPM calc) in MNI and Talairach space. Wilcoxson test statistics (Wilcox) was calculated between the cluster sizes of hypometabolism at z > 3, the asterisk indicates a significance of p < 0.05
