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Figure 1 | BioMedical Engineering OnLine

Figure 1

From: Computational modeling of peripheral pain: a commentary

Figure 1

Experimental results yielded by different studies can be combined to build an alternative representation of the pain circuitry. Unidirectional synaptic connections among superficial dorsal horn neurons have been reported by Lu and coworkers (red bordered panels) [2629]. Each study per se only provides a piece of information on neuron connectivity at that region, but these pieces can be put together, by identifying the elements they have in common, to build a network reflecting some of the interactions that actually contribute to noxious information processing (bottom panel). EC excitatory central cell, Gly glycinergic neuron, HTC high-threshold C-fiber, I islet cell, IC inhibitory central cell, LTC low-threshold C-fiber, P projection neuron, PKCγ neuron expressing the γ-isoform of protein kinase C, V vertical cell.

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