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Table 5 Comparison of per-patient clinical results and virtual trial simulations (self-validation and cross validation) on Glucontrol B. Clinical and actual measurements were taken 63.5% of the potential per-protocol specified times based on glycemic results. Median [IQR] is used where appropriate.

From: Validation of a model-based virtual trials method for tight glycemic control in intensive care

  

Self validation

Cross validation

 

Clinical

Actual measurement

Per protocol

Per protocol

No. of patients

69

69

69

142

Per Patient Results

Insulin rate (U/h)

0.6 [0.3 - 1.2]

0.5 [0.2 - 1.0]

0.6 [0.2 - 1.4]

0.2 [0.0 - 0.8]

Glucose rate (g/h)

2.9 [0.7 - 7.4]

2.9 [0.7 - 7.4]

2.9 [0.7 - 7.4]

1.1 [0.5 - 7.5]

BG (mmol/L)

8.3 [7.6 - 8.8]

8.4 [7.8 - 9.1]

8.7 [8.1 - 9.5]

8.3 [7.4 - 9.1]

BG measures

2820

2820

4448

5772

Measurement frequency

(measurement/patient/day)

5.23

5.23

8.23

8.23