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Table 5 Comparison of per-patient clinical results and virtual trial simulations (self-validation and cross validation) on Glucontrol B. Clinical and actual measurements were taken 63.5% of the potential per-protocol specified times based on glycemic results. Median [IQR] is used where appropriate.

From: Validation of a model-based virtual trials method for tight glycemic control in intensive care

   Self validation Cross validation
  Clinical Actual measurement Per protocol Per protocol
No. of patients 69 69 69 142
Per Patient Results
Insulin rate (U/h) 0.6 [0.3 - 1.2] 0.5 [0.2 - 1.0] 0.6 [0.2 - 1.4] 0.2 [0.0 - 0.8]
Glucose rate (g/h) 2.9 [0.7 - 7.4] 2.9 [0.7 - 7.4] 2.9 [0.7 - 7.4] 1.1 [0.5 - 7.5]
BG (mmol/L) 8.3 [7.6 - 8.8] 8.4 [7.8 - 9.1] 8.7 [8.1 - 9.5] 8.3 [7.4 - 9.1]
BG measures 2820 2820 4448 5772
Measurement frequency
(measurement/patient/day)
5.23 5.23 8.23 8.23