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Table 4 Comparison of per-patient clinical results and virtual trial simulations (self-validation and cross validation) on Glucontrol A. Clinical and actual measurements were taken 52.0% of the potential per-protocol specified times based on in silico glycemic results. Median [IQR] is used where appropriate.

From: Validation of a model-based virtual trials method for tight glycemic control in intensive care

   Self validation Cross validation
  Clinical Actual Measurement Per-Protocol Per-Protocol
No. of patients 142 142 142 69
Per Patient Results
Insulin rate (U/h) 1.4 [0.9 - 2.1] 1.8 [1.1 - 2.9] 2.5 [1.5 - 4.1] 4.5 [2.3 - 6.5]
Glucose rate (g/h) 1.1 [0.5 - 7.6] 1.1 [0.5 - 7.6] 1.1 [0.5 - 7.6] 2.9 [0.7 - 7.4]
BG (mmol/L) 6.4 [5.9 - 6.9] 6.2 [5.7 - 6.8] 6.2 [5.7 - 6.8] 6.5 [6.0 - 6.9]
BG measures 4564 4564 9467 7259
Measurement frequency
(measurement/patient/day)
6.52 6.52 13.54 13.48