Table 4 Comparison of per-patient clinical results and virtual trial simulations (self-validation and cross validation) on Glucontrol A. Clinical and actual measurements were taken 52.0% of the potential per-protocol specified times based on in silico glycemic results. Median [IQR] is used where appropriate.
From: Validation of a model-based virtual trials method for tight glycemic control in intensive care
| Â | Â | Self validation | Cross validation | |
|---|---|---|---|---|
| Â | Clinical | Actual Measurement | Per-Protocol | Per-Protocol |
No. of patients | 142 | 142 | 142 | 69 |
Per Patient Results | ||||
Insulin rate (U/h) | 1.4 [0.9 - 2.1] | 1.8 [1.1 - 2.9] | 2.5 [1.5 - 4.1] | 4.5 [2.3 - 6.5] |
Glucose rate (g/h) | 1.1 [0.5 - 7.6] | 1.1 [0.5 - 7.6] | 1.1 [0.5 - 7.6] | 2.9 [0.7 - 7.4] |
BG (mmol/L) | 6.4 [5.9 - 6.9] | 6.2 [5.7 - 6.8] | 6.2 [5.7 - 6.8] | 6.5 [6.0 - 6.9] |
BG measures | 4564 | 4564 | 9467 | 7259 |
Measurement frequency (measurement/patient/day) | 6.52 | 6.52 | 13.54 | 13.48 |