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Table 2 Negative challenge in 70-Kg type-1 diabetics.

From: In silico evaluation of a control system and algorithm for automated insulin infusion in the ICU setting

   Undershoot (glycemia < 60 mg × dL -1 ) Overshoot (Glycemia > 140 mg × dL -1 )
Challenge Hepatic Sensitivity (Sh) Peak (mg × dL -1 ) Duration (min) T S * (min) Peak (mg × dL -1 ) Duration (min) T S * (min)
10 units of regular insulin administered intravenously in 2 seconds 0.7 10 2 22 no no n/a
  0.5 12 5 60 no no n/a
  0.3 31 7 45 no no n/a
  1. Note the inter-individual variations with hepatic sensitivity changes.
  2. (*) TS = settling time, minutes after the start of the challenge for the glycemia to return to the 90-120 mg × dL-1 range