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Table 1 Positive challenges.

From: In silico evaluation of a control system and algorithm for automated insulin infusion in the ICU setting

    Overshoot (Glycemia > 140 mg × dL -1 ) Undershoot (glycemia < 60 mg × dL -1 )
Type of Challenge Weight (Kg) Hepatic Sensitivity (Sh) Peak (mg × dL -1 ) Duration (min) T S * (min) Peak (mg × dL -1 ) Duration (min) T S * (min)
   0.7 144 38 72 no no n/a
  80 0.5 154 72 95 no no n/a
   0.3 168 102 144 no no n/a
   0.7 144 30 90 no no n/a
Mild ¶ 70 0.5 150 30 90 no no n/a
   0.3 163 84 135 no no n/a
   0.7 143 22 42 no no n/a
  60 0.5 150 46 66 no no n/a
   0.3 159 72 108 no no n/a
   0.7 164 54 72 no no n/a
  80 0.5 172 76 92 no no n/a
   0.3 182 86 108 no no n/a
   0.7 163 50 70 no no n/a
Moderate § 70 0.5 170 30 60 no no n/a
   0.3 181 78 96 no no n/a
   0.7 162 50 70 no no n/a
  60 0.5 170 58 72 no no n/a
   0.3 183 72 84 no no n/a
   0.7 170 30 31 no no n/a
  80 0.5 176 36 37 no no n/a
   0.3 177 41 42 no no n/a
   0.7 175 30 55 no no n/a
Severe † 70 0.5 180 15 120 no no n/a
   0.3 191 36 39 no no n/a
   0.7 189 30 31 no no n/a
  60 0.5 188 29 30 no no n/a
   0.3 201 36 38 no no n/a
  1. Note the inter-individual variations with body weight and/or hepatic sensitivity changes.
  2. (bold) The two rows in bold numbers are the ones represented in Figures 4 and 5 respectively
  3. (*) TS = settling time, minutes for the glycemia to return to the 90-120 mg × dL-1 range
  4. (¶) Mild challenge = 50 g of oral carbohydrate (from 50 g of starch)
  5. (§) 50 g of oral glucose (250 g of grapes)
  6. (†) 10 g intravenous glucose (20 mL of 50% dextrose in water) in 30 seconds