Table 4 Metabolic reaction fluxes (mmol/min) estimated under resting steady-state conditions from flux balance analysis and reaction maximal velocities (mmol/min) estimated under resting steady-state conditions from reaction fluxes for three different loading states.

φ_GLU→G6P

0.182

V _GLY→G6P

0.46

0.557

0.557

φ_G6P→GLY

0.258

V _G6P→GLY

2.58

3.42

2.58

φ_GLY→G6P

0.258

V _GLY→G6P

1.72

1.72

2.08

φ_G6P→GA3P

0.182

V _G6P→GA3P

1.63

1.45

1.91

φ_GA3P→BPG

0.363

V _GA3P→BPG

48.0

48.0

48.0

φ_BPG→PYR

0.363

V _BPG→PYR

25.4

25.4

25.4

φ_PYR→LAC

0.294

V _PYR→LAC

8.81

6.86

8.81

φ_LAC→PYR

0.182

V _LAC→PYR

1.09

0.85

1.09

φ_PYR→ALA

0.04

V _PYR→ALA

0.12

0.12

0.16

φ_PYR→ACoA

0.217

V _PYR→ACoA

15.2

15.2

15.2

φ_TGL→GLC

0.13

V _TGL→GLC

0.65

0.823

0.65

φ_GLC→TGL

0.127

V _GLC→TGL

1.78

2.31

1.78

φ_FFA→FAC

0.095

V _FFA→FAC

1.33

1.73

1.06

φ_FAC→ACoA

0.095

V _FAC→ACoA

0.951

1.2

0.768

φ_ACoA→CIT

0.978

V _ACoA→CIT

6.84

9.54

5.71

φ_CIT→AKG

0.978

V _CIT→AKG

9.78

14.2

8.22

φ_AKG→SCoA

0.978

V _AKG→SCoA

13.7

19.1

11.4

φ_SCoA→SUC

0.978

V _SCoA→SUC

13.7

19.1

11.4

φ_SUC→MAL

0.978

V _SUC→MAL

5.87

8.8

4.89

φ_MAL→OXA

0.978

V _MAL→OXA

5.87

8.8

4.89

φ_O2→H2O

2.75

V _O2→H2O

24.6

35.2

20.3

φ_PCR→CR

667.0

V _PCR→CR

4000.0

4000.0

4000.0

φ_CR→PCR

667.0

V _CR→PCR

4000.0

4000.0

4000.0

φ_ATP→ADP

16.0

V _ATP→ADP

16.2

16.2

16.2

φ_AMP→ADP

50.0

V _AMP→ADP

250.0

250.0

250.0

φ_ADP→AMP

50.0

V _ADP→AMP

250.0

250.0

250.0