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Table 2 Effects of inotropic drugs before and after global ischemia on morphological and temporal indices [5]

From: Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts

Before Ischemia After Ischemia
Con Dbt Dop Dig Lev Con Dbt Dop Dig Lev
Heart Rate (beats per minute)
236 ± 3 350 ± 12* 298 ± 9* 259 ± 6 270 ± 5* 242 ± 8 350 ± 15# 298 ± 13# 269 ± 10 271 ± 7
Systolic LVP (mmHg)
32 ± 1 73 ± 5* 55 ± 3* 49 ± 2* 51 ± 2* 29 ± 2 44 ± 3# 40 ± 1# 37 ± 2# 35 ± 2#
Diastolic LVP (mmHg)
3 ± 1 2 ± 1 4 ± 1 6 ± 1 3 ± 2 13 ± 2† 13 ± 2† 13 ± 2† 14 ± 1† 18 ± 2†
Phasic (systolic-diastolic) LVP (mmHg)
28 ± 2 71 ± 6* 52 ± 3* 43 ± 1* 48 ± 3* 16 ± 2† 32 ± 4# 27 ± 2# 23 ± 2# 17 ± 3†
Systolic [Ca2+] (nM)
258 ± 4 609 ± 48* 307 ± 14* 301 ± 10* 367 ± 31* 381 ± 27† 544 ± 56# 310 ± 19# 333 ± 22 369 ± 24
Diastolic [Ca2+] (nM)
103 ± 2 140 ± 10* 108 ± 4 106 ± 2 110 ± 3 124 ± 9† 148 ± 13 107 ± 9 100 ± 6# 124 ± 10
Phasic (systolic-diastolic) [Ca2+] (nM)
155 ± 5 469 ± 72* 198 ± 12* 194 ± 10* 257 ± 32* 257 ± 19† 396 ± 53# 204 ± 20 234 ± 17 245 ± 23
  1. Values are expressed as mean ± SE. [CaCl2] was 1.25 mM. Con = Control, Dbt = Dobutamine, Dop = Dopamine, Dig = Digoxin, Lev = Levosimendan. Statistical significance was measured at *p < 0.05 vs. Control before ischemia, #p < 0.05 vs. Control after ischemia, †p < 0.05 after vs. before ischemia for all groups.