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Table 2 Effects of inotropic drugs before and after global ischemia on morphological and temporal indices [5]

From: Ischemia reperfusion dysfunction changes model-estimated kinetics of myofilament interaction due to inotropic drugs in isolated hearts

Before Ischemia

After Ischemia

Con

Dbt

Dop

Dig

Lev

Con

Dbt

Dop

Dig

Lev

Heart Rate (beats per minute)

236 ± 3

350 ± 12*

298 ± 9*

259 ± 6

270 ± 5*

242 ± 8

350 ± 15#

298 ± 13#

269 ± 10

271 ± 7

Systolic LVP (mmHg)

32 ± 1

73 ± 5*

55 ± 3*

49 ± 2*

51 ± 2*

29 ± 2

44 ± 3#†

40 ± 1#†

37 ± 2#†

35 ± 2#†

Diastolic LVP (mmHg)

3 ± 1

2 ± 1

4 ± 1

6 ± 1

3 ± 2

13 ± 2†

13 ± 2†

13 ± 2†

14 ± 1†

18 ± 2†

Phasic (systolic-diastolic) LVP (mmHg)

28 ± 2

71 ± 6*

52 ± 3*

43 ± 1*

48 ± 3*

16 ± 2†

32 ± 4#†

27 ± 2#†

23 ± 2#†

17 ± 3†

Systolic [Ca2+] (nM)

258 ± 4

609 ± 48*

307 ± 14*

301 ± 10*

367 ± 31*

381 ± 27†

544 ± 56#

310 ± 19#

333 ± 22

369 ± 24

Diastolic [Ca2+] (nM)

103 ± 2

140 ± 10*

108 ± 4

106 ± 2

110 ± 3

124 ± 9†

148 ± 13

107 ± 9

100 ± 6#

124 ± 10

Phasic (systolic-diastolic) [Ca2+] (nM)

155 ± 5

469 ± 72*

198 ± 12*

194 ± 10*

257 ± 32*

257 ± 19†

396 ± 53#

204 ± 20

234 ± 17

245 ± 23

  1. Values are expressed as mean ± SE. [CaCl2] was 1.25 mM. Con = Control, Dbt = Dobutamine, Dop = Dopamine, Dig = Digoxin, Lev = Levosimendan. Statistical significance was measured at *p < 0.05 vs. Control before ischemia, #p < 0.05 vs. Control after ischemia, †p < 0.05 after vs. before ischemia for all groups.