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Figure 7 | BioMedical Engineering OnLine

Figure 7

From: Regional differences in APD restitution can initiate wavebreak and re-entry in cardiac tissue: A computational study

Figure 7

Predicted upper and lower bounds for initiating wavebreak in models. (a) Predicted upper (red) and lower (blue) bounds for model with steep APD restitution. The modified upper bound (solid red line) used information from the delays shown in (b). (b) Conduction delays measured in heterogenous tissue with two regions of steep APD restitution. Delays are delayS2S3, for S3 action potentials at CLS2S3 close to those that result in block in R1, and each line shows this delay for a different S1 S2 interval. Region R2 is to the left of the dotted grey line, and region R1 to the right. See text for details. (c) Predicted upper (red) and lower (blue) bounds for model with flat APD restitution. The modified upper bound (solid red line) used information from the delays shown in (d). (d) Conduction delays measured in heterogeneous tissue with flat restitution. See text for details.

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