TY - JOUR AU - Kuise, Takashi AU - Noguchi, Hirofumi AU - Tazawa, Hiroshi AU - Kawai, Takashi AU - Iwamuro, Masaya AU - Saitoh, Issei AU - Usui Kataoka, Hitomi AU - Watanabe, Masami AU - Noguchi, Yasufumi AU - Fujiwara, Toshiyoshi PY - 2014 DA - 2014/05/27 TI - Establishment of a pancreatic stem cell line from fibroblast-derived induced pluripotent stem cells JO - BioMedical Engineering OnLine SP - 64 VL - 13 IS - 1 AB - For cell therapies to treat diabetes, it is important to produce a sufficient number of pancreatic endocrine cells that function similarly to primary islets. Induced pluripotent stem (iPS) cells represent a potentially unlimited source of functional pancreatic endocrine cells. However, the use of iPS cells for laboratory studies and cell-based therapies is hampered by their high tumorigenic potential and limited ability to generate pure populations of differentiated cell types in vitro. The purpose of this study was to establish a pancreatic stem cell line from iPS cells derived from mouse fibroblasts. SN - 1475-925X UR - https://doi.org/10.1186/1475-925X-13-64 DO - 10.1186/1475-925X-13-64 ID - Kuise2014 ER -