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Table 1 Cluster statistics for cross-sectional group comparison

From: Impact of the control for corrupted diffusion tensor imaging data in comparisons at the group level: an application in Huntington disease

cl.

  

Visit 1

Visit 2

Visit 3

Visit 1 (QC)

Visit 2 (QC)

Visit 3 (QC)

1

basal ganglia

R

4,337

5,143

4,491

4,579

5,356

4,551

 

MNI (x/y/z)

 

20/-6/-2

18/-7/-2

20/-7/-1

21/-6/-2

19/-8/-2

23/3/3

2

basal ganglia

L

3,997

2,574

2,553

4,287

2,873

2,571

 

MNI (x/y/z)

 

−19/-8/-3

−18/-7/-4

−25/2/7

−19/-8/-3

−25/3/7

−24/3/6

3

thalamic region internal capsule

R/L

40,800

1,617

84,048

7,961

1,665

5,560

 

MNI (x/y/z)

 

34/-17/-13

34/-18/-11

35/-19/-12

35/-18/-12

34/-18/-11

35/-18/-12

4

thalamic region

R

within cl. 3

within cl. 11

within cl. 3

32,070

1,289

within cl. 11

 

MNI (x/y/z)

    

−3/-14/4

−19/-10/9

 

5

thalamic region

R

within cl. 3

within cl. 11

within cl. 3

1,859

within cl. 11

within cl. 11

 

MNI (x/y/z)

    

25/4/-13

  

6

thalamic region

R

1,072

within cl. 11

within cl. 3

738

within cl. 11

within cl. 11

 

MNI (x/y/z)

 

16/-40/4

  

16/-41/4

  

7

thalamic region

L

13,094

4,770

within cl. 3

11,640

2,743

4,622

 

MNI (x/y/z)

 

−21/-21/-15

−20/-22/-13

 

−21/-21/-13

−20/-22/-13

−23/-21/-11

8

internal capsule

L

within cl. 7

432

within cl. 3

within cl. 7

335

within cl. 11

 

MNI (x/y/z)

  

18/-9/12

  

18/-9/12

 

9

external capsule

L

within cl. 7

within cl. 11

within cl. 3

within cl. 7

1,406

within cl. 11

 

MNI (x/y/z)

     

−35/-15/7

 

10

external capsule

R

255

within cl. 11

within cl. 3

272

within cl. 11

within cl. 11

 

MNI (x/y/z)

 

36/-13/8

  

34/7/2

  

11

CC

R/L

1,400

41,508

within cl. 3

3426

35,008

37705

 

MNI (x/y/z)

 

−9/18/12

−11/-25/25

 

−7/17/13

−11/-25/25

−27/-56/19

12

occipital lobe

R

2,210

2,026

3,166

2,160

2,015

1,845

 

MNI (x/y/z)

 

35/-89/-8

38/-74/-5

38/-71/-7

34/-88/-8

38/-75/-4

37/-73/-6

13

occipital lobe

L

1,685

1,027

within cl. 3

2,010

950

891

 

MNI (x/y/z)

 

−40/-68/2

−39/-69/2

 

−41/-68/1

−39/-69/2

−40/-67/1

14

frontal lobe

L

no cluster

294

497

373

280

453

 

MNI (x/y/z)

  

−34/27/6

−41/29/-1

−40/29/1

−34/27/6

−41/29/-1

15

limbic lobe

L

no cluster

no cluster

within cl. 11

296

422

within cl. 11

 

MNI (x/y/z)

    

−16/0/37

−15/3/35

 

16

parietal lobe

L

682

no cluster

within cl. 11

within cl. 3

within cl. 11

within cl. 11

 

MNI (x/y/z)

 

−18/-49/34

     

17

occipital lobe

L

643

319

within cl. 3

283

307

within cl. 13

 

MNI (x/y/z)

 

−22/-81/22

−22/-80/24

 

−23/-82/22

−22/-80/23

 

18

temporal lobe

L

205

no cluster

within cl. 3

172

1279

203

 

MNI (x/y/z)

 

−46/-52/3

  

−47/-50/3

−48/-53/5

−46/-51/7

19

parietal lobe

R

230

no cluster

311

256

no cluster

317

 

MNI (x/y/z)

 

19/-64/49

 

19/-61/47

19/-62/50

 

18/-63/49

20

internal capsule

R/L

195

no cluster

no cluster

no cluster

no cluster

no cluster

 

MNI (x/y/z)

 

−10/6/-6

     

21

hippocampus

R

192

no cluster

no cluster

no cluster

no cluster

no cluster

 

MNI (x/y/z)

L

−26/-20/-26

     
  1. Clusters (cl.) of the FA map group comparison between HD subjects and controls (cl. size/voxels and MNI coordinates of the area with highest significance). All clusters listed in this table show a p-value of p < 0.001. Basically, several cluster groups that are interconnected in different analyses were found. Clusters 1,2 (FA increase): clusters located in the basal ganglia. Clusters 3-17 (FA reduction): clusters covering the thalamic area, external and internal capsule, and corpus callosum (CC); additional clusters in the occipital, frontal, parietal lobe, and limbic regions. Clusters 18-21 (FA reduction): small clusters in the temporal and parietal lobe, the internal capsule, and the hippocampus.