Table 1 The rules of interactions in the C.elegans early embryonic cell cycles network.
From: Boolean genetic network model for the control of C. elegans early embryonic cell cycles
Effector | Effected | Activation | Inhibition |
|---|---|---|---|
cdc-14/fzy-1 | cdk-1/cyclinB | Â | fzy-1 is able to activate the APC (anaphase-promoting complex), which is for cyclin B degradation. -1 [10] |
cdc-14/fzy-1 | fzr-1 | fzy-1 and fzr-1 encode orthologous proteins to Cdc20 and Cdh1 respectively in S. cerevisiae. The Interaction is inferred from the yeast cell-cycle network. 1 [2] | Â |
cdc-14/fzy-1 | cki-1 | cdc-14 upregulates cki-1 for accumulation. 1 [11] | Â |
cdc-25.1 | cdk-2/cyclinE | cdc-25.1 activates cdk-2 by dephosphorylation. 1 [12] | Â |
cdc-25.1 | cdk-1/cyclinB | cdc-25.1 activates cdk-1 by dephosphorylation. 1 [12] | Â |
cdk-1/cyclinB | cdc-14/fzy-1 | Cyclin B and cdc-14 are orthologous to Clb1,2 and Cdc14, respectively. Interaction inferred from the yeast cell-cycle network. 1 [2] | Â |
cdk-2/cyclinE | cul-1/lin-23 | cul-1 and lin-23 encode a Skp1-Cul1-F box (SCF) protein complex. SCF will be turned on for cyclin E degradation when exiting from S phase. Here we infer that cdk-2/cyclinE triggers SCF. 1 [13] | Â |
cdk-2/cyclinE | lin-35/efl-1/dpl-1 | Â | Inhibits -1 [11] |
cdk-2/cyclinE | cdc-14/fzy-1 | Â | Cyclin E suppresses the expression of cdc-14. -1 [14] |
cki-1 | cdk-2/cyclinE | Â | cki-1 encodes CDK inhibitory proteins which is rate limiting for S phase entry. -1 [13] |
cki-1 | cdk-1/cyclinB | Â | cki-1 encodes CDK inhibitory proteins. Inhibit activity of cdk-1. -1 [15] |
cki-1 | cki-1 | Â | Add a self-degradation due to no inhibitory interaction on this node. This method was used in Li's model. -1 [2] |
cul-1/lin-23 | cdk-2/cyclinE | Â | cul-1 and lin-23 encode a Skp1-Cul1-F box (SCF) protein complex for cyclin E degradation. -1 [13] |
cul-1/lin-23 | cdc-25.1 | Â | lin-23 negatively regulates the abundance of cdc-25.1. -1 [16] |
cul-1/lin-23 | cul-1/lin-23 | Â | Add self-degradation. -1 |
cul-1/lin-23 | lin-35/efl-1/dpl-1 | A synthetic interaction between lin-23 and lin-35. 1 [17] | Â |
fzr-1 | cdk-1/cyclinB | Â | Loss of fzr-1 will decrease APC which is for cyclin B degradation. -1 [17] |
fzr-1 | fzr-1 | Â | Add self-degradation. -1 |
fzr-1 | cki-1 | fzr-1 promotes accumulation of cki-1. 1 [13] | Â |
lin-35/efl-1/dpl-1 | cdk-2/cyclinE | Â | lin-35 negatively regulates cye-1. -1[11] |
lin-35/efl-1/dpl-1 | cdk-1/cyclinB | efl-1/dpl-1 promotes expression of cyclin B. 1 [18] | Â |