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Table 1 Values of the model parameters

From: A multi-scale cardiovascular system model can account for the load-dependence of the end-systolic pressure-volume relationship

Parameter

Value

Units

Source

Intracellular calcium concentration

T 1

40.6

ms

Fit from [17]

T 2

130.2

ms

Fit from [17]

Ca max

1.47

μM

Fit from [17]

Chemical kinetics

Y 1

39

μM s–1

[15]

Z 1

30

s–1

[15]

Y 2

1.3

s–1

[15]

Z 2

1.3

s–1

[15]

Y 3

30

s–1

[15]

Z 3

1560

μM s–1

[15]

Y 4

40

s–1

[15]

Y d

8

s μm–2

[15]

T t

70

μM

[15]

B

800

s–1

[15]

h c

0.005

μm

[15]

L a

1.17

μm

[15]

R

20

μm–2

[15]

Cross-bridge parallel and elastic forces

A

1800

mN mm–2 μm–1 μM–1

[15]

K

140 000

mN mm–2 μm–5

[15]

L 0

0.97

μm

[15]

α

0.5

mN mm–2

[15]

β

75

μm–1

[15]

Force-length to pressure-volume conversion

K v

29.0

ml μm–3

Adjusted

L r

1.05

μm

[15]

V w

60.6

ml

Computed from [6]

f

0.217

-

Adjusted

Hemodynamic parameters

E pa

0.953

mmHg ml–1

Adjusted

E pu

0.0302

mmHg ml–1

Adjusted

E ao

0.965

mmHg ml–1

Adjusted

E vc

0.0107

mmHg ml–1

Adjusted

E rv

2.06

mmHg ml–1

Computed from [6, 18]

R pul

2.74

mmHg s ml–1

Computed from [6, 18]

R sys

5.65

mmHg s ml–1

Computed from [6, 18]

R av

0.152

mmHg s ml–1

Adjusted

R mt

0.0313

mmHg s ml–1

Adjusted

R pv

0.0269

mmHg s ml–1

Adjusted

R tc

0.459

mmHg s ml–1

Adjusted

Total blood volume

1500

ml

[19]

Right ventricle driver function

A 1

0.956

-

[3]

A 2

0.625

-

[3]

A 3

0.0180

-

[3]

B 1

255

s–2

[3]

B 2

225

s–2

[3]

B 3

4230.0

s–2

[3]

C 1

0.431

s

Adapted from [3]

C 2

0.328

s

Adapted from [3]

C 3

0.374

s

Adapted from [3]

Cardiac period

0.6

s

[3]

  1. These values have been taken as such from the literature or have been adjusted by an iterative process (see text for details).