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Figure 4 | BioMedical Engineering OnLine

Figure 4

From: Different responses to mechanical injury in neonatal and adult ovine articular cartilage

Figure 4

Quantitative real-time PCR measurement of differential gene expression. Adult injury (AI), adult control (AC), neonatal injury (NI), and neonatal control (NC). Quantification of transcript abundance indicates significant up-regulation of PPARγ (A), HIF1-A (B), LDH (C), TOM (D), SMAD7 (E), and NFκB (F) gene expression in neonatal injured articular cartilage compared with adult articular cartilage. The RT-qPCR data for all six target genes confirmed the results of microarray hybridization experiments. Mathematical means of expression are indicated below each age group, and mean fold differences for each target gene are also given numerically as ‘Mean FC’ under the abscissa. Two-sided t tests and an ANOVA were used for statistical analyses. *P values < 0.05 were considered statistically significant.

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