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Table 5 Estimation results for the two-compartment model parameters K 1 , k 2 , k 3 , and k 4 with noise level α = 0.4, using different cut-off frequencies and 250 noise realizations

From: Fourier domain closed-form formulas for estimation of kinetic parameters in reversible multi-compartment models

Cut-off frequency index k c

K 1(min -1)

k 2(min -1)

k 3(min -1)

k 4(min -1)

K 1 (k 3 + k 4 ) /(k 2 k 4 )

K 1 k 3 /(k 2 k 4 )

k 3 /k 4

8

0.36 ± 0.05

0.22 ± 0.10

0.11 ± 0.09

0.07 ± 0.03

4.08 ± 0.07

2.24 ± 0.55

1.43 ± 0.77

10

0.37 ± 0.05

0.24 ± 0.11

0.13 ± 0.08

0.08 ± 0.03

4.07 ± 0.07

2.35 ± 0.49

1.58 ± 0.77

15

0.37 ± 0.04

0.23 ± 0.09

0.11 ± 0.08

0.07 ± 0.03

4.07 ± 0.07

2.27 ± 0.51

1.45 ± 0.71

20

0.37 ± 0.03

0.22 ± 0.08

0.10 ± 0.08

0.06 ± 0.03

4.08 ± 0.07

2.24 ± 0.51

1.39 ± 0.65

True

0.40

0.30

0.20

0.10

4.00

2.67

2.00