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Table 2 Action potential features of experimental and simulated action potentials

From: Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes

 

Early

Late

Delta %

 

Exp

Sim

Exp

Sim

Exp

Sim

APD 30 (ms)

117 (107÷132)

121

163 (84÷256)

165

+ 40

+ 36

APD 50 (ms)

169 (149÷184)

163

258 (148÷374)

224

+ 53

+ 37

APD 70 (ms)

205 (181÷219)

191

325 (179÷465)

283

+ 59

+ 48

APD 90 (ms)

229 (216÷241)

225

419 (223÷506)

350

+ 83

+ 56

Vmax (mV/s)

4610 (3308÷5612)

4123

5566 (5198÷7047)

5620

+ 42

+ 36

MDP (mV)

-55 (-62÷-37)

-76

-51 (-62÷-42)

-73

-7

- 4

DDR (mV/s)

14.4 (11.1÷28.4)

9.7

9.9 (8.0÷11.1)

7.1

- 31

- 27

F (bpm)

27 (23÷53)

29

22 (20÷29)

24

- 17

- 17

  1. Delta %, Late VS Early; APD, action potential duration; Vmax maximum upstroke velocity; MDP maximum diastolic potential; DDR diastolic depolarization rate; F frequency. Data reported as median and interquartile. All the experimental action potential features were measured on hESC-CM AP at the Early and Late stage [50].