Mathematical modelling of the action potential of human embryonic stem cell derived cardiomyocytes

Table 1 Main developmental changes of ionic currents

	Parameter (units)	Early	Late	Adult [16]	Species [Ref.]
I _to	G_to (S/F) max conductance	19.2929	48.702	294	human, EXP, †; human, MOD, [16]
I _Kr	G_Kr (S/F) max conductance	288.0	134.4	96	rat, guinea pig, EXP, [24] ; human, MOD, [16]
I _f ^*2;	G_f (S/F) max conductance	49	20.913	-	human, EXP, [6]
I _K1 ^*2;	G_K1 (S/F) max conductance	240.523	1154.508	5405	human, EXP, [6] ; human, MOD, [16]
I _CaL ^*2;	G_CaL (dm³/(F⋅s)) permeability	0.0438	0.0739	0.175	mouse, EXP, [24] ; human, EXP. [6] human, MOD, [16]
I _CaT	G_CaT (S/F) max conductance	45.8	9.16	-	human, EXP, † ; rabbit, MOD, [27]
I _NaCa ^*2;	I_maxNaCa (A/F) max current	17500	18240	1000	human, EXP, † ; human, MOD, [16]
I _Na	G_Na (S/F) max conductance	563.844	14838	14838	mouse, EXP, [24] ; human, MOD, [16]
I _Ks	G_Ks (S/F) max conductance	15.7	15.7	157	human, EXP, [32] ; human, MOD, [16]
I _NaK	I_maxNaK (A/F) max current	0.9534	1.1305	1.362	mouse, EXP, [34] ; human, MOD, [16]
I _pCa	G_pCa (S/F) max conductance	0.825, §	0.825, §	25	human, MOD, [16]
I _up	I_maxUp (mM/s) max flux	0.0565	0.1403	0.425	mouse, EXP, [24] ; human, MOD, [16]
I _rel	I_maxRel (mM/s) max flux	0.274	9.88	24.7	mouse, EXP, [24] ; human, MOD, [16]
I _leak	I_maxLeak (1/s) max rate	0.0004	0.024	0.08	mouse, EXP, [24] ; human, MOD, [16]
I _bCa	G_bCa (S/F) max conductance	0.118, §	0.592, §	0.592	human, MOD, [16]

Maximum conductances, currents and fluxes for Early and Late human embryonic stem cell-derived and adult ventricular cardiomyocyte models. The species considered for the Early and Late date are reported. Adult data refers to the TenTusscher model [16]. † new measurements and data; § values chosen to reproduce at best the AP shape; ^*2; not only the maximal conductance/current was changed but also the current formulation (see Additional file 1). EXP: experimental data; MOD: used for modelling.

ISSN: 1475-925X