Figure 3

Increase of MMP-2 expression in human saphenous vein grafts after exposure to arterial pressure. HSVGs were perfused with venous (10 mmHg, white bar) or arterial (100 mmHg, black bars) pressure profiles for the indicated time relative to the unperfused controls of the same veins, respectively. 10 mmHg 1 day (n = 5), 10 mmHg 3 days (n = 3), 10 mmHg 5 days (n = 4), 100 mmHg 1 day (n = 3), 100 mmHg 3 days (n = 5), 100 mmHg 5 days (n = 4). The MMP-2/β-actin ratio in unperfused veins was arbitrarily set to 1.