Figure 3

Algorithm for the Non-Uniform Illumination correction on retinal images. The algorithm starts by fitting a smoothing spline (1) to the input image. The input image is divided by (1), generating a flatten image (2). The approximate location of drusen spots are then estimated applying an Otsu Threshold (3) to the generated image. These areas are then replaced in the input image by the spline (1), producing a new image (4) with reduced influence of the drusen bright areas. The next iteration uses this new input image and executes the same procedure a predefined number of iterations to generate the final image.