Figure 6
Illustration of variables that can be measured in one animal using the ABST system. Multiple physiological variables including blood pressure (BP), heart rate (HR), temperature (Temp), locomotion, activity and various biopotential leads e.g. electrocardiographs (ECG), electroencephalographs (EEG) electromyographs (EMG), or electroretinographs (ERG) can be measured in one rat concomitantly with plasma and metabolic waste. Plasma and urine samples can be used for determination of drug concentration time course and characterization of multiple biochemical endpoints such as clinical pathology, urinary renal biomarkers as well as metabonomics. If the study requires histopathology, genomic and proteomic endpoints, target organ samples are available at the end of the "live phase".