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Table 1 Nomenclature from Equations 2 and 3

From: A graphical method for practical and informative identifiability analyses of physiological models: A case study of insulin kinetics and sensitivity

Symbol

definition

units

I

Plasma insulin concentration

mU/L

Q

Interstitial insulin concentration

mU/L

U N

Endogenous insulin production rate profile

mU/L/min

U X

Exogenous insulin bolus

mmol

n K

Renal clearance of plasma insulin

1/min

n L

Hepatic clearance of plasma insulin

1/min

n C

Insulin clearance to cells

1/min

n I

Transition of insulin between plasma and interstitium

L/min

α I

Saturation of hepatic insulin clearance

L/mU

x L

First pass clearance of insulin

1

V P

Distribution volume of plasma insulin

L

V Q

Distribution volume of interstitial insulin

L